Synthetic Mimics of Antimicrobial Peptides from Triaryl Scaffolds
نویسندگان
چکیده
منابع مشابه
Antibacterial Peptidomimetics: Polymeric Synthetic Mimics of Antimicrobial Peptides
Polymer-based peptidomimetics, or proteinomimetics, are a relatively young and dynamic field of research. The ability to successfully mimic the biochemical activity of antimicrobial peptides (AMPs) has been demonstrated by several groups. This has been accomplished by careful tuning of the molecule’s hydrophobicity and charge density. At the same time, many important questions remain to be answ...
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The design and generation of molecules capable of mimicking the binding and/or functional sites of proteins represents a promising strategy for the exploration and modulation of protein function through controlled interference with the underlying molecular interactions. Synthetic peptides have proven an excellent type of molecule for the mimicry of protein sites because such peptides can be gen...
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ژورنال
عنوان ژورنال: Journal of Medicinal Chemistry
سال: 2011
ISSN: 0022-2623,1520-4804
DOI: 10.1021/jm101410t